{"id":295,"date":"2021-09-16T08:49:43","date_gmt":"2021-09-16T00:49:43","guid":{"rendered":"http:\/\/phosphoramidite.cn\/en\/?p=295"},"modified":"2021-09-16T08:51:20","modified_gmt":"2021-09-16T00:51:20","slug":"ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline","status":"publish","type":"post","link":"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/","title":{"rendered":"IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline"},"content":{"rendered":"\n<p>author: Namit Chaudhary , Drew Weissman and Kathryn A. Whitehead<\/p>\n\n\n\n<p>Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts.<br>Although it is now clear that mRNA vaccines can rapidly and safely protect patients from infectious disease, additional research is required to optimize mRNA design, intracellular delivery and applications beyond SARS-CoV-2 prophylaxis. In this Review, we describe the technologies that underlie mRNA vaccines, with an emphasis on lipid nanoparticles and other non-viral delivery vehicles. We also overview the pipeline of mRNA vaccines against various infectious disease pathogens and discuss key questions for the future application of this breakthrough vaccine platform.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"693\" height=\"358\" src=\"http:\/\/phosphoramidite.cn\/en\/wp-content\/uploads\/2021\/09\/mRNA-production-flow.png\" alt=\"\" class=\"wp-image-296\" srcset=\"https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNA-production-flow.png 693w, https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNA-production-flow-300x155.png 300w\" sizes=\"auto, (max-width: 693px) 100vw, 693px\" \/><figcaption>mRNA production flow<\/figcaption><\/figure>\n\n\n<p class=\"wp-block-tag-cloud\"><a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/3-deoxyadenosine\/\" class=\"tag-cloud-link tag-link-23 tag-link-position-1\" style=\"font-size: 8pt;\" aria-label=\"3\u2019-deoxyadenosine (1 item)\">3\u2019-deoxyadenosine<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/abogen\/\" class=\"tag-cloud-link tag-link-33 tag-link-position-2\" style=\"font-size: 8pt;\" aria-label=\"Abogen (1 item)\">Abogen<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/cansino-biologics\/\" class=\"tag-cloud-link tag-link-29 tag-link-position-3\" style=\"font-size: 8pt;\" aria-label=\"Cansino biologics (1 item)\">Cansino biologics<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/conference\/\" class=\"tag-cloud-link tag-link-36 tag-link-position-4\" style=\"font-size: 8pt;\" aria-label=\"Conference (1 item)\">Conference<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/cordycepin\/\" class=\"tag-cloud-link tag-link-22 tag-link-position-5\" style=\"font-size: 8pt;\" aria-label=\"Cordycepin (1 item)\">Cordycepin<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/coronavirus-vaccine\/\" class=\"tag-cloud-link tag-link-31 tag-link-position-6\" style=\"font-size: 8pt;\" aria-label=\"Coronavirus Vaccine (1 item)\">Coronavirus Vaccine<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/covid-19\/\" class=\"tag-cloud-link tag-link-30 tag-link-position-7\" style=\"font-size: 8pt;\" aria-label=\"COVID-19 (1 item)\">COVID-19<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/dntps\/\" class=\"tag-cloud-link tag-link-27 tag-link-position-8\" style=\"font-size: 8pt;\" aria-label=\"dNTPs (1 item)\">dNTPs<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/exhibition\/\" class=\"tag-cloud-link tag-link-37 tag-link-position-9\" style=\"font-size: 8pt;\" aria-label=\"Exhibition (1 item)\">Exhibition<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/gmp-site\/\" class=\"tag-cloud-link tag-link-28 tag-link-position-10\" style=\"font-size: 8pt;\" aria-label=\"GMP site (1 item)\">GMP site<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/immorna\/\" class=\"tag-cloud-link tag-link-24 tag-link-position-11\" style=\"font-size: 8pt;\" aria-label=\"Immorna (1 item)\">Immorna<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/investment\/\" class=\"tag-cloud-link tag-link-25 tag-link-position-12\" style=\"font-size: 8pt;\" aria-label=\"investment (1 item)\">investment<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/lnp\/\" class=\"tag-cloud-link tag-link-21 tag-link-position-13\" style=\"font-size: 8pt;\" aria-label=\"LNP (1 item)\">LNP<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/mrna\/\" class=\"tag-cloud-link tag-link-19 tag-link-position-14\" style=\"font-size: 22pt;\" aria-label=\"mRNA (5 items)\">mRNA<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/ntps\/\" class=\"tag-cloud-link tag-link-26 tag-link-position-15\" style=\"font-size: 8pt;\" aria-label=\"NTPs (1 item)\">NTPs<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/nucleosides\/\" class=\"tag-cloud-link tag-link-15 tag-link-position-16\" style=\"font-size: 8pt;\" aria-label=\"Nucleosides (1 item)\">Nucleosides<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/nucleotides\/\" class=\"tag-cloud-link tag-link-16 tag-link-position-17\" style=\"font-size: 8pt;\" aria-label=\"Nucleotides (1 item)\">Nucleotides<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/oligo\/\" class=\"tag-cloud-link tag-link-20 tag-link-position-18\" style=\"font-size: 8pt;\" aria-label=\"Oligo (1 item)\">Oligo<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/oligonucleotides\/\" class=\"tag-cloud-link tag-link-14 tag-link-position-19\" style=\"font-size: 8pt;\" aria-label=\"Oligonucleotides (1 item)\">Oligonucleotides<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/phosphoramidite\/\" class=\"tag-cloud-link tag-link-17 tag-link-position-20\" style=\"font-size: 8pt;\" aria-label=\"Phosphoramidite (1 item)\">Phosphoramidite<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/phosphoramidites\/\" class=\"tag-cloud-link tag-link-13 tag-link-position-21\" style=\"font-size: 8pt;\" aria-label=\"Phosphoramidites (1 item)\">Phosphoramidites<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/rna-sequences\/\" class=\"tag-cloud-link tag-link-10 tag-link-position-22\" style=\"font-size: 8pt;\" aria-label=\"RNA sequences (1 item)\">RNA sequences<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/solid-phase-synthesis\/\" class=\"tag-cloud-link tag-link-11 tag-link-position-23\" style=\"font-size: 8pt;\" aria-label=\"Solid-phase synthesis (1 item)\">Solid-phase synthesis<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/synthesis-of-oligonucleotides\/\" class=\"tag-cloud-link tag-link-12 tag-link-position-24\" style=\"font-size: 8pt;\" aria-label=\"synthesis of oligonucleotides (1 item)\">synthesis of oligonucleotides<\/a>\n<a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/vaccine\/\" class=\"tag-cloud-link tag-link-32 tag-link-position-25\" style=\"font-size: 8pt;\" aria-label=\"Vaccine (1 item)\">Vaccine<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>author: Namit Chaudhary , Drew Weissman and Kathryn A. Whitehead Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts.Although it is now clear that &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\"> <span class=\"screen-reader-text\">IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-295","post","type-post","status-publish","format-standard","hentry","category-product"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline - Nucleic acid Building Block<\/title>\n<meta name=\"description\" content=\"Nucleic acid Building Block IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline - Nucleic acid Building Block\" \/>\n<meta property=\"og:description\" content=\"Nucleic acid Building Block IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\" \/>\n<meta property=\"og:site_name\" content=\"Nucleic acid Building Block\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-16T00:49:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-16T00:51:20+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/phosphoramidite.cn\/en\/wp-content\/uploads\/2021\/09\/mRNA-production-flow.png\" \/>\n<meta name=\"author\" content=\"Nugene\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@AndyLu_Pharma\" \/>\n<meta name=\"twitter:site\" content=\"@AndyLu_Pharma\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nugene\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\"},\"author\":{\"name\":\"Nugene\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/9c38cfb28c26135316aa34152190c0d3\"},\"headline\":\"IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline\",\"datePublished\":\"2021-09-16T00:49:43+00:00\",\"dateModified\":\"2021-09-16T00:51:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\"},\"wordCount\":144,\"publisher\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/#organization\"},\"articleSection\":[\"Product\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\",\"url\":\"https:\/\/nugene.com.cn\/en\/index.php\/ivt-mrna-is-formulated-into-lipid-nanoparticle-vaccines-using-a-cell-free-production-pipeline\/\",\"name\":\"IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline - 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