{"id":282,"date":"2021-09-13T11:26:02","date_gmt":"2021-09-13T03:26:02","guid":{"rendered":"http:\/\/phosphoramidite.cn\/en\/?p=282"},"modified":"2021-09-13T11:26:03","modified_gmt":"2021-09-13T03:26:03","slug":"timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug","status":"publish","type":"post","link":"https:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/","title":{"rendered":"Timeline of some key discoveries and advances in the development of mRNA-based drug"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"575\" src=\"http:\/\/phosphoramidite.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-1024x575.png\" alt=\"\" class=\"wp-image-283\" srcset=\"https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-1024x575.png 1024w, https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-300x168.png 300w, https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-768x431.png 768w, https:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory.png 1151w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Timeline of some key discoveries and advances in the development of mRNA-based drug technology. Green boxes represent discoveries and advances in mRNA mechanisms; blue boxes represent discoveries and advances in mRNA-based drug applications. Abbreviations: mRNA, messenger RNA; 5\u2032 cap, five-prime cap; LNP, lipid nanoparticles; COVID-19, coronavirus disease 2019; DCs, dendritic cells.<\/li><li>Int. J. Mol. Sci. 2020, 21, 6582<\/li><\/ul>\n\n\n<div class=\"taxonomy-post_tag wp-block-post-terms\"><a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/lnp\/\" rel=\"tag\">LNP<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/mrna\/\" rel=\"tag\">mRNA<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/nugene.com.cn\/en\/index.php\/tag\/oligo\/\" rel=\"tag\">Oligo<\/a><\/div>\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/patisiran\/\">Patisiran<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/givosiran\/\">Givosiran<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/lumasiran-sodium\/\">Lumasiran sodium<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/inclisiran-sodium\/\">Inclisiran sodium<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/vutrisiran\/\">Vutrisiran<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Timeline of some key discoveries and advances in the development of mRNA-based drug technology. Green boxes represent discoveries and advances in mRNA mechanisms; blue boxes represent discoveries and advances in mRNA-based drug applications. Abbreviations: mRNA, messenger RNA; 5\u2032 cap, five-prime cap; LNP, lipid nanoparticles; COVID-19, coronavirus disease 2019; DCs, dendritic cells. Int. J. Mol. Sci. &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\"> <span class=\"screen-reader-text\">Timeline of some key discoveries and advances in the development of mRNA-based drug<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"categories":[6,9],"tags":[21,19,20],"class_list":["post-282","post","type-post","status-publish","format-standard","hentry","category-news","category-rd","tag-lnp","tag-mrna","tag-oligo"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block<\/title>\n<meta name=\"description\" content=\"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block\" \/>\n<meta property=\"og:description\" content=\"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug\" \/>\n<meta property=\"og:url\" content=\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\" \/>\n<meta property=\"og:site_name\" content=\"Nucleic acid Building Block\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-13T03:26:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-13T03:26:03+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/phosphoramidite.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-1024x575.png\" \/>\n<meta name=\"author\" content=\"Nugene\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@AndyLu_Pharma\" \/>\n<meta name=\"twitter:site\" content=\"@AndyLu_Pharma\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nugene\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\"},\"author\":{\"name\":\"Nugene\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/9c38cfb28c26135316aa34152190c0d3\"},\"headline\":\"Timeline of some key discoveries and advances in the development of mRNA-based drug\",\"datePublished\":\"2021-09-13T03:26:02+00:00\",\"dateModified\":\"2021-09-13T03:26:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\"},\"wordCount\":66,\"publisher\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/#organization\"},\"keywords\":[\"LNP\",\"mRNA\",\"Oligo\"],\"articleSection\":[\"News\",\"R&amp;D\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\",\"url\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\",\"name\":\"Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block\",\"isPartOf\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/#website\"},\"datePublished\":\"2021-09-13T03:26:02+00:00\",\"dateModified\":\"2021-09-13T03:26:03+00:00\",\"description\":\"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug\",\"breadcrumb\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/nugene.com.cn\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Timeline of some key discoveries and advances in the development of mRNA-based drug\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#website\",\"url\":\"http:\/\/nugene.com.cn\/en\/\",\"name\":\"Nucleic acid Building Block\",\"description\":\"service@nugene.com.cn; Hangzhou, China\",\"publisher\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/nugene.com.cn\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#organization\",\"name\":\"Nugene Biopharm Science\",\"url\":\"http:\/\/nugene.com.cn\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/logo\/image\/\",\"url\":\"http:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/08\/logo-2.png\",\"contentUrl\":\"http:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/08\/logo-2.png\",\"width\":180,\"height\":60,\"caption\":\"Nugene Biopharm Science\"},\"image\":{\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/twitter.com\/AndyLu_Pharma\",\"https:\/\/www.linkedin.com\/company\/nugene\/?viewAsMember=true\"]},{\"@type\":\"Person\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/9c38cfb28c26135316aa34152190c0d3\",\"name\":\"Nugene\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/77e83bf7d0179f279a53024575c03c3f0d494286cd7fa13fb5028c7a47287950?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/77e83bf7d0179f279a53024575c03c3f0d494286cd7fa13fb5028c7a47287950?s=96&d=mm&r=g\",\"caption\":\"Nugene\"},\"sameAs\":[\"http:\/\/phosphoramidite.cn\/en\"],\"url\":\"https:\/\/nugene.com.cn\/en\/index.php\/author\/dragonbio\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block","description":"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/","og_locale":"en_US","og_type":"article","og_title":"Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block","og_description":"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug","og_url":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/","og_site_name":"Nucleic acid Building Block","article_published_time":"2021-09-13T03:26:02+00:00","article_modified_time":"2021-09-13T03:26:03+00:00","og_image":[{"url":"http:\/\/phosphoramidite.cn\/en\/wp-content\/uploads\/2021\/09\/mRNAhistory-1024x575.png"}],"author":"Nugene","twitter_card":"summary_large_image","twitter_creator":"@AndyLu_Pharma","twitter_site":"@AndyLu_Pharma","twitter_misc":{"Written by":"Nugene","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#article","isPartOf":{"@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/"},"author":{"name":"Nugene","@id":"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/9c38cfb28c26135316aa34152190c0d3"},"headline":"Timeline of some key discoveries and advances in the development of mRNA-based drug","datePublished":"2021-09-13T03:26:02+00:00","dateModified":"2021-09-13T03:26:03+00:00","mainEntityOfPage":{"@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/"},"wordCount":66,"publisher":{"@id":"http:\/\/nugene.com.cn\/en\/#organization"},"keywords":["LNP","mRNA","Oligo"],"articleSection":["News","R&amp;D"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/","url":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/","name":"Timeline of some key discoveries and advances in the development of mRNA-based drug - Nucleic acid Building Block","isPartOf":{"@id":"http:\/\/nugene.com.cn\/en\/#website"},"datePublished":"2021-09-13T03:26:02+00:00","dateModified":"2021-09-13T03:26:03+00:00","description":"Nucleic acid Building Block Timeline of some key discoveries and advances in the development of mRNA-based drug","breadcrumb":{"@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/nugene.com.cn\/en\/index.php\/timeline-of-some-key-discoveries-and-advances-in-the-development-of-mrna-based-drug\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/nugene.com.cn\/en\/"},{"@type":"ListItem","position":2,"name":"Timeline of some key discoveries and advances in the development of mRNA-based drug"}]},{"@type":"WebSite","@id":"http:\/\/nugene.com.cn\/en\/#website","url":"http:\/\/nugene.com.cn\/en\/","name":"Nucleic acid Building Block","description":"service@nugene.com.cn; Hangzhou, China","publisher":{"@id":"http:\/\/nugene.com.cn\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/nugene.com.cn\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"http:\/\/nugene.com.cn\/en\/#organization","name":"Nugene Biopharm Science","url":"http:\/\/nugene.com.cn\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/nugene.com.cn\/en\/#\/schema\/logo\/image\/","url":"http:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/08\/logo-2.png","contentUrl":"http:\/\/nugene.com.cn\/en\/wp-content\/uploads\/2021\/08\/logo-2.png","width":180,"height":60,"caption":"Nugene Biopharm Science"},"image":{"@id":"http:\/\/nugene.com.cn\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/twitter.com\/AndyLu_Pharma","https:\/\/www.linkedin.com\/company\/nugene\/?viewAsMember=true"]},{"@type":"Person","@id":"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/9c38cfb28c26135316aa34152190c0d3","name":"Nugene","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/nugene.com.cn\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/77e83bf7d0179f279a53024575c03c3f0d494286cd7fa13fb5028c7a47287950?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/77e83bf7d0179f279a53024575c03c3f0d494286cd7fa13fb5028c7a47287950?s=96&d=mm&r=g","caption":"Nugene"},"sameAs":["http:\/\/phosphoramidite.cn\/en"],"url":"https:\/\/nugene.com.cn\/en\/index.php\/author\/dragonbio\/"}]}},"_links":{"self":[{"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/posts\/282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/comments?post=282"}],"version-history":[{"count":1,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/posts\/282\/revisions"}],"predecessor-version":[{"id":284,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/posts\/282\/revisions\/284"}],"wp:attachment":[{"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/media?parent=282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/categories?post=282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nugene.com.cn\/en\/index.php\/wp-json\/wp\/v2\/tags?post=282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}