Synthesis of Phosphate-Branched Oligonucleotides
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solidsupported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry. Phosphorodialkylamidites 1-3 may in principle be used in …
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