Modified Nucleoside

Fluoro Modified Nucleoside

Item No.Short NameChemical NameFormulaMolecular WeightCAS NO
H105C-002′-F-2′-dA2′-Fluoro-2′-DeoxyadenosineC10H12FN5O3269.2464183-27-3
H205C-002′-F-2′-dC2′-Fluoro-2′-DeoxycytidineC9H12FN3O4245.2110212-20-1
H305C-002′-F-2′-dG2′-Fluoro-2′-DeoxyguanosineC10H12FN5O4 285.2378842-13-4
H405C-002′-F-2′-dU2′-Fluoro-2′-DeoxyuridineC9H11FN2O5246.2784-71-4

O-Methyl Modified Nucleoside

Item No.Chemical NameFormulaMolecular WeightCAS NO
H103C-002′-O-MethyladenosineC11H15N5O4281.272140-79-6
H203C-002′-O-MethylcytidineC10H15N3O5257.242140-72-9
H303C-002′-O-MethylguanosineC11H15N5O5297.272140-71-8
H403C-002′-O-MethyluridineC10H14N2O6258.232140-76-3
H903C-002′-O-Me-5-Me-CytidineC11H17N3O5271.27113886-70-7

Modified nucleoside refers to a nucleoside molecule that has undergone chemical modifications to its structure. Nucleosides are building blocks of nucleic acids, DNA and RNA, consisting of a nitrogenous base and a five-carbon sugar molecule (ribose or deoxyribose). In modified nucleosides, the nitrogenous base or the sugar has been altered by adding or removing functional groups, which can affect the base pairing and hydrogen bonding properties of the nucleotide. These modified nucleosides can occur naturally in some organisms or can be engineered by synthetic biology techniques. They have various biological functions, such as regulating gene expression, providing chemical stability, or modulating enzymatic activity. Modified nucleosides are being studied for their potential applications in gene therapy, drug development, and synthetic biology.

Nugene as a part of Zhejiang Hengkang Pharmaceutical, provides modified nucleoside in large-scale, our modified nucleoside is used in CMO/CDMO industry for phosphoramidite mononer that is key materials for synthesis of Oligonucleotide, such as ASO, siRNA, etc. The high quality help clients to prepare high purity and low mutation ASO and siRNA, accelerate R&D and save cost.

Packing size: 1kg/bag, 5kg/bag, 15kg/bag.