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Nugene Biopharm Science providepseudouridine-5′-Triphosphate solution 100mM Sodium and 200mM Tris for RNA synthesis, mRNA synthesis, IVT.Packing size: 1mL, 10mL, 20mL, 100mL, 1L, etc.GMP management as per API manufacturing, approved Chinese FDA. Molecular Formula: C9H15N2O15P3Molecular Mass: 484.144 InChIInChI=N/A InChIKeyInChIKey=VEWJOCYCKIZKKV-GBNDHIKLSA-N Other Names for this Substance Bioactivity: MODERNA THERAPEUTICS INC – US2021/38529, 2021, A1

Nugene Biopharm Science provide Adenosine 5′-triphosphate solution 100mM Sodium and 200mM Tris for RNA synthesis, mRNA synthesis, IVT.Packing size: 1mL, 10mL, 20mL, 100mL, 1L, etc.GMP management as per API manufacturing, approved Chinese FDA. Molecular Formula: C10H16N5O13P3Molecular Mass: 507.18 InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 InChIKeyInChIKey=ZKHQWZAMYRWXGA-KQYNXXCUSA-N SMILESO[C@H]1C@N=CN3)(OC@HO)(=O)O)(=O)O)[C@H]1O)[H] Canonical SMILESO=P(O)(O)OP(=O)(O)OP(=O)(O)OCC1OC(N2C=NC=3C(=NC=NC32)N)C(O)C1O Other Names for this SubstanceAdenosine 5′-(tetrahydrogen triphosphate)Adenosine 5′-triphosphateAdenosine triphosphateAdenosine 5′-triphosphoric acidAtipi

Recently, Baoshan District, Shanghai, signed a contract with Lanque Biotechnology(Rnacure) to build an mRNA clinical drug R&D and GMP production base . Lanque Biology will plan and build a 5000 square meter R&D center and a 10,000 square meter GMP production base in Songnan Town and Luodian Town respectively, forming a spatial layout of “Southern …

Lanque Bio（Rnacure) signed a contract with Shanghai Baoshan District to build an mRNA clinical drug R&D and production base Read More »

Cunningham et al. reported 3’-deoxyadenosine(Cordycepin) was first isolated from the culture filtrate of the medicinal fungus Cordyceps militaris in 1950.Herba Su has been identified as one of the important active ingredients of Cordyceps militaris.Cordycepin has a wide range of medical and health care values.Its medicine Physical activity includes anti-cancer, anti-metastasis, anti-tumor, anti-apoptosis, anti-inflammatory.Cordycepin can also …

Cordycepin Read More »

Mol Pharm . 2015 Jun 1;12(6):2010-8. doi: 10.1021/mp5008212. Epub 2015 Apr 28. D33-targeted lipid nanoparticles (aCD33LNs) were synthesized for delivery of GTI-2040, an antisense oligonucleotide (ASO) against the R2 subunit of ribonucleotide reductase, to acute myelogenous leukemia (AML). These LNs incorporated a deoxycholate-polyethylenimine (DOC-PEI) conjugate, which has shown significant activity to facilitate oligonucleotide delivery. Anti-CD33 scFv (aCD33) was …

Lipid Nanoparticles for Therapeutic Delivery of GTI-2040 Read More »

author: Namit Chaudhary , Drew Weissman and Kathryn A. Whitehead Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts.Although it is now clear that …

IVT mRNA is formulated into lipid nanoparticle vaccines using a cell-free production pipeline Read More »

A new labelling technique attaching fluorescein via a carbamoyl linker directly to the amino groups of the nucleobases was developed. The amino groups were first converted to the phenoxycarbonyl derivatives (
10,15, 19, 58), which reacted under mild conditions with 5-aminofluorescein to give the corresponding N-[(fluorescein-5-ylamino)carbonyl] derivatives (
11 ± 14, 16, 17, 20, 59, 60). The …

A New Type of Labelling of Nucleosides and Nucleotides Read More »