News of Phosphoramidite for RNAi
INDUSTRY’S LARGEST & MOST RENOWNED EVENT TO ACCELERATE YOUR THERAPEUTICS TO MARKET: LEADING STRATEGIES FOR EXPEDITING R&D AND IMPROVING CMC EFFICIENCY INDUSTRY-LEADING SPEAKERS SHARE CUTTING-EDGE SCIENCE AND PROGRESS Moderna, BioNTech, Ionis, Aro Biotherapeutics, Alnylam, Bicycle Therapeutics, Intellia will speak. San Diego, CA, USA May 7-10, 2023 Agenda Drug Delivery Innovations Explore new technologies and approaches …
People familiar with the matter said that relevant consultations are still in progress, and details such as the scale and timing of fundraising may be adjusted. A spokesperson for the SoftBank Vision Fund declined to comment, and representatives of Abogen and Mirae Asset did not immediately respond to requests for comment or were unable to …
Dec 23, 2021，CanSino Biologics Inc. announced that The Lancet published its Phase III clinical trial results on the safety and efficacy of its Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (“Ad5-nCoV”, trade name: Convidecia™). The publication of the analysis showed that a single dose of Convidecia™ is efficacious and safe with an efficacy of 96.0% in preventing …
Nugene Biopharm Science (Hangzhou) Co., Ltd. is investing 200 million yuan to build a commercial production base and a research and development center, that can meet the urgently needed supply of key raw materials in the mRNA industry chain. The 6000 square meter research and development center has been completed, providing global mRNA customers with …
GMP site for the urgently needed supply of key raw materials in the mRNA industry chain Read More »
“I think the research and development of innovative new drugs requires a long-term process. You can stand on the shoulders of giants to gain certain advantages, but it is impossible overnight. Investors choose Jiachen Xihai to value our stable construction and vision.” In early 2021, Jiachen Xihai announced the completion of a series A financing …
Immorna announced the completion of a round A financing of more than RMB 100 million Read More »
Nugene biopharma science provide 3’-deoxyadenosine, Cordycepin.
Timeline of some key discoveries and advances in the development of mRNA-based drug technology. Green boxes represent discoveries and advances in mRNA mechanisms; blue boxes represent discoveries and advances in mRNA-based drug applications. Abbreviations: mRNA, messenger RNA; 5′ cap, five-prime cap; LNP, lipid nanoparticles; COVID-19, coronavirus disease 2019; DCs, dendritic cells. Int. J. Mol. Sci. …
Timeline of some key discoveries and advances in the development of mRNA-based drug Read More »
Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediatestrong, transient protein expression with minimal induction of the innate immune response and risk for genome integration.modRNA is already being used in several human clinical trials, and its use in basic and translational science is growing.Due …
Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy Read More »
Novel Phosphoramidite Building Blocks in Synthesis and Applications Toward Modified Oligonucleotides Natarajan Venkatesan, Su Jeong Kim and Byeang Hyean Kim In recent years modified oligonucleotides (oligos) have become an area of increased research activity. These synthetic biopolymers have long been used as molecular probes to understand better the interaction between proteins and nucleic acids at …
A solid-phase synthesis for phosphate-branched oligonucleotides is described. The method is based on coupling of a single nucleoside phosphorodiamidite to terminal hydroxyl functions of two solidsupported oligonucleotides. After oxidation of the phosphite triester obtained to a phosphate triester, the third branch is assembled by conventional phosphoramidite chemistry. Phosphorodialkylamidites 1-3 may in principle be used in …
Synthesis of Phosphate-Branched Oligonucleotides Read More »
