{"id":299,"date":"2022-05-10T16:57:57","date_gmt":"2022-05-10T08:57:57","guid":{"rendered":"http:\/\/nugene.com.cn\/cn\/?p=299"},"modified":"2022-05-10T16:58:00","modified_gmt":"2022-05-10T08:58:00","slug":"%e5%a6%82%e4%bd%95%e4%bf%9d%e9%9a%9c%e5%85%a8%e7%90%83mrna%e7%96%ab%e8%8b%97%e7%a0%94%e5%8f%91%e5%92%8c%e7%94%9f%e4%ba%a7%e9%9c%80%e6%b1%82%ef%bc%9f","status":"publish","type":"post","link":"http:\/\/nugene.com.cn\/cn\/index.php\/%e5%a6%82%e4%bd%95%e4%bf%9d%e9%9a%9c%e5%85%a8%e7%90%83mrna%e7%96%ab%e8%8b%97%e7%a0%94%e5%8f%91%e5%92%8c%e7%94%9f%e4%ba%a7%e9%9c%80%e6%b1%82%ef%bc%9f\/","title":{"rendered":"\u5982\u4f55\u4fdd\u969c\u5168\u7403mRNA\u75ab\u82d7\u7814\u53d1\u548c\u751f\u4ea7\u9700\u6c42\uff1f"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>\u6838\u82af\u751f\u7269\u533b\u836f\u79d1\u6280\uff08\u676d\u5dde\uff09\u6709\u9650\u516c\u53f8\u6c47\u603b<\/p>\n\n\n\n<p>\u4ee580\u4ebf\u5242\u8ba1\u7b97\uff0c\u7edf\u8ba1\u5bf9\u6bd4\u4e863\u5bb6\u4e3b\u6d41\u7684mRNA\u75ab\u82d7\u5e02\u573a\u6210\u672c\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table><tbody><tr><td>\u9879\u76ee<\/td><td>mRNA-1273<\/td><td>BNT162b2<\/td><td>CVnCoV<\/td><\/tr><tr><td>\u751f\u4ea7\u57fa\u5730<\/td><td>14<\/td><td>5<\/td><td>2<\/td><\/tr><tr><td>\u751f\u4ea7\u7ebf\u6570\u91cf<\/td><td>55<\/td><td>17<\/td><td>7<\/td><\/tr><tr><td>mRNA\u539f\u6599\/Kg<\/td><td>842.1<\/td><td>252.6<\/td><td>101.1<\/td><\/tr><tr><td>\u751f\u4ea7\u6279\u6b21<\/td><td>10175<\/td><td>3145<\/td><td>1295<\/td><\/tr><tr><td>\u4eba\u5458<\/td><td>4620<\/td><td>1386<\/td><td>554<\/td><\/tr><tr><td>\u539f\u6599\u6210\u672c<\/td><td>31.9\u4ebf\u7f8e\u5143<\/td><td>9.85\u4ebf\u7f8e\u5143<\/td><td>4.06\u4ebf\u7f8e\u5143<\/td><\/tr><tr><td>\u539f\u6599\u751f\u4ea7\u6210\u672c<\/td><td>174.8\u4ebf\u7f8e\u5143<\/td><td>54.0\u4ebf\u7f8e\u5143<\/td><td>22.2\u4ebf\u7f8e\u5143<\/td><\/tr><tr><td>\u5206\u88c5\u6210\u672c<\/td><td>21.6\u4ebf\u7f8e\u5143<\/td><td>30.4\u4ebf\u7f8e\u5143<\/td><td>21.6\u4ebf\u7f8e\u5143<\/td><\/tr><tr><td>\u603b\u6210\u672c<\/td><td>228.3\u4ebf\u7f8e\u5143<\/td><td>94.3\u4ebf\u7f8e\u5143<\/td><td>43.8\u4ebf\u7f8e\u5143<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u5176\u4e2dmRNA-1273\uff0c\u5242\u91cf\u4e3a100\u5fae\u514b\uff0cBNT162b2\u4e3a30\u5fae\u514b\uff0cCVnCoV\u4e3a12\u5fae\u514b\u3002<\/p>\n\n\n\n<p>\u4f5c\u4e3a\u539f\u6599\u836f\u751f\u4ea7\u5927\u56fd\uff0c\u7279\u522b\u5173\u6ce8mRNA\u539f\u6750\u6599\u7684\u6210\u672c\u5360\u6bd4\uff0c\u6c47\u603b\u4e86\u524d10\u540d\u5982\u4e0b<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table><tbody><tr><td>\u5e8f\u53f7<\/td><td>\u539f\u6750\u6599<\/td><td>80\u4ebf\u5242\u6210\u672c\/\u767e\u4e07\u7f8e\u5143<\/td><td>\u5360\u6bd4<\/td><\/tr><tr><td>1<\/td><td>\u5e3d\u7c7b\u4f3c\u7269<\/td><td>5887<\/td><td>44.7%<\/td><\/tr><tr><td>2<\/td><td>\u4fee\u9970\u6838\u82f7\u9178<\/td><td>2931<\/td><td>22.2%<\/td><\/tr><tr><td>3<\/td><td>DNA\u6a21\u677f<\/td><td>1762<\/td><td>13.3%<\/td><\/tr><tr><td>4<\/td><td>T7\u805a\u5408\u9176<\/td><td>728<\/td><td>5.52%<\/td><\/tr><tr><td>5<\/td><td>\u53ef\u7535\u79bb\u8102\u8d28<\/td><td>627<\/td><td>4.76%<\/td><\/tr><tr><td>6<\/td><td>\u7126\u78f7\u9178\u9176<\/td><td>424<\/td><td>3.22%<\/td><\/tr><tr><td>7<\/td><td>ATP<\/td><td>160<\/td><td>1.22%<\/td><\/tr><tr><td>8<\/td><td>GTP<\/td><td>160<\/td><td>1.22%<\/td><\/tr><tr><td>9<\/td><td>CTP<\/td><td>159<\/td><td>1.22%<\/td><\/tr><tr><td>10<\/td><td>\u80c6\u56fa\u9187<\/td><td>135<\/td><td>1.03%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u76ee\u524d\u5728mRNA\u6280\u672f\u9886\u57df\uff0c\u6838\u5fc3\u6280\u672f\u5305\u62ec\uff0cmRNA\u5e8f\u5217\u8bbe\u8ba1\u3001\u5e3d\u7c7b\u4f3c\u7269\u5408\u6210\u3001\u4fee\u9970\u6838\u82f7\u9178\u8bbe\u8ba1\u548c\u5408\u6210\u3001\u9012\u9001\u7cfb\u7edf\u8bbe\u8ba1\u548c\u914d\u65b9\u3001\u9012\u9001\u539f\u6599\u53ef\u7535\u79bb\u8102\u8d28\u5408\u6210\u548c\u7eaf\u5ea6\u3002<\/p>\n\n\n\n<p>\u6838\u82af\u751f\u7269\u56e2\u961f\u5728\u6709\u673a\u5408\u6210\u548c\u7eaf\u5316\u5236\u5907\u9886\u57df\u6df1\u8015\u4e8c\u5341\u591a\u5e74\uff0c\u5df2\u7ecf\u5b9e\u73b0\u4ea7\u4e1a\u5316\u4ea7\u54c1\u6709\uff0c\u5e3d\u7c7b\u4f3c\u7269\uff08\u5428\u7ea7\u522b\uff09\u3001\u4fee\u9970\u6838\u82f7\u9178\uff08\u5428\u7ea7\u522b\uff09\u3001\u53ef\u7535\u79bb\u8102\u8d28\uff08\u767e\u514b\u7ea7\u522b\uff09\uff0c\u6838\u82f7\u9178\uff08\u5428\u7ea7\u522b\uff09\uff0c\u516c\u53f8\u7a81\u7834\u4e86\u89c4\u6a21\u5316\u751f\u4ea7\u7684\u6240\u6709\u9ad8\u96be\u5ea6\u75db\u70b9\uff0c\u5176\u751f\u4ea7\u4ea7\u80fd\u53ef\u4ee5\u4e3a\u5168\u7403\u6240\u6709mRNA\u7814\u53d1\u548c\u751f\u4ea7\u4f01\u4e1a\u7a33\u5b9a\u4f9b\u5e94\u76f8\u5e94\u539f\u6599\u3002<\/p>\n\n\n\n<p>mRNA\u5e8f\u5217\u8bbe\u8ba1\uff0c\u4ee5\u65b0\u51a0\u75ab\u82d7\u4e3a\u4f8b\uff0c1273\u4e2a\u6c28\u57fa\u9178\uff0c\u5bfc\u81f4\u5019\u9009mRNA\u5e8f\u5217\u8d85\u8fc710<sup>632<\/sup>\u4e2a\uff0c\u5bf9\u4e8e\u533b\u836f\u516c\u53f8\u6765\u8bf4\u8fd9\u662f\u5929\u6587\u91cf\u7ea7\u7684\u8ba1\u7b97\uff0c\u76ee\u524d\u8be5\u9886\u57df\u7f3a\u4e4f\u4eba\u624d\uff0c\u5927\u6709\u53ef\u4e3a\u3002<\/p>\n\n\n\n<p>\u5e3d\u7c7b\u4f3c\u7269\u548c\u4fee\u9970\u6838\u82f7\u9178\u5408\u6210\u548c\u7eaf\u5ea6\uff0c\u4ee5\u5e02\u552e\u53ef\u5f97\u7684\u6709\u673a\u5316\u5408\u7269\u548c\u6eb6\u5242\u4e3a\u8d77\u59cb\u7269\u6599\uff0c\u7ecf\u8fc7\u8d85\u8fc718\u6b65\u7684\u53cd\u5e94\u548c\u7eaf\u5ea6\u64cd\u4f5c\uff0c\u603b\u6536\u7387\u548c\u5468\u671f\u5341\u5206\u6f2b\u957f\uff0c\u751a\u81f3\u53ef\u8fbe3\u4e2a\u6708\u3002\u5982\u679c\u8fd9\u90e8\u5206\u6210\u672c\u65e0\u6cd5\u4e0b\u964d\uff0cmRNA\u60e0\u53ca\u5168\u4eba\u7c7b\u5c06\u662f\u5927\u6311\u6218\u3002<\/p>\n\n\n\n<p>\u6838\u82f7\u9178\u7c7b\u4f3c\u7269\u8bbe\u8ba1\uff0c\u4ee5\u5c3f\u5627\u5576\u7c7b\u4f3c\u7269\u7684\u6548\u679c\u8f83\u597d\u3001\u5e94\u7528\u6700\u591a\uff0c\u5047\u5c3f\u82f7\u548cN1-\u7532\u57fa-\u5047\u5c3f\u82f7\u662fBioNtech\u548cModerna\u4f7f\u7528\uff0c\u6709\u7ecf\u9a8c\u53ef\u5faa\u3002\u6838\u82af\u751f\u7269\u533b\u836f\u6a21\u5757\u5316\u6280\u672f\u5e73\u53f0\uff0c\u53ef\u4e3a\u5ba2\u6237\u63d0\u4f9b\u5176\u4ed6\u5c3f\u5627\u5576\u7c7b\u4f3c\u7269\u5feb\u901f\u5408\u6210\u548c\u5236\u5907\uff01<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"692\" height=\"612\" src=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5168\u65b0\u4fee\u9970\u5c3f\u82f7\u9178-1.jpg\" alt=\"\" class=\"wp-image-301\" srcset=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5168\u65b0\u4fee\u9970\u5c3f\u82f7\u9178-1.jpg 692w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5168\u65b0\u4fee\u9970\u5c3f\u82f7\u9178-1-300x265.jpg 300w\" sizes=\"auto, (max-width: 692px) 100vw, 692px\" \/><\/figure>\n\n\n\n<p>\u9012\u9001\u7cfb\u7edf\uff0cLNP \u7ed3\u6784\u548c\u6210\u5206\u6bd4\u4f8b\u51b3\u5b9a\u6027\u80fd\u597d\u574f\u3002\u79bb\u5b50\u5316\u8102\u8d28\u5206\u5b50\u7684\u5e94\u7528\u5219\u5b9e\u73b0\u4e86 LNP \u6280\u672f\u7684\u7a81\u7834\uff0c\u5b83\u7684\u6781\u6027\u4f1a\u968f pH \u503c\u53d8\u5316\u800c\u6539\u53d8\uff0c\u5728\u751f\u7406pH \u503c\u4e0b\u4fdd\u6301\u4e2d\u6027\uff0c\u5728 LNP \u88ab\u7ec6\u80de\u541e\u5165\u5f62\u6210\u5185\u4f53\u540e\uff0cpH \u503c\u4f1a\u964d\u4f4e\uff0c\u53ef\u79bb\u5b50\u5316\u8102\u8d28\u5206\u5b50\u4f1a\u643a\u5e26\u6b63\u7535\u8377\uff0c\u6539\u53d8 LNP \u7ed3\u6784\u4fc3\u8fdb mRNA \u91ca\u653e\u5230\u7ec6\u80de\u57fa\u8d28\u5185\u5b8c\u6210\u6297\u539f\u86cb\u767d\u7ffb\u8bd1\u3002\u6838\u82af\u751f\u7269\u533b\u836f\u5df2\u7ecf\u4e3a\u5168\u7403\u5ba2\u6237\u5b9a\u5236\u5ba2\u6237\u8bbe\u8ba1\u7684\u53ef\u7535\u79bb\u8102\u8d28\u5206\u5b50\uff0c\u6a21\u5757\u5316\u6280\u672f\u5e73\u53f0\u7a81\u7834\u5408\u6210\u548c\u5236\u5907\u7eaf\u5316\u96be\u70b9\uff0c\u4e3a\u5ba2\u6237\u63d0\u4f9b\u9ad8\u7eaf\u5ea6\u3001\u7a33\u5b9a\u6027\u826f\u597d\u7684\u4ea7\u54c1\uff01<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"765\" height=\"391\" src=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/LNP0510.png\" alt=\"\" class=\"wp-image-302\" srcset=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/LNP0510.png 765w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/LNP0510-300x153.png 300w\" sizes=\"auto, (max-width: 765px) 100vw, 765px\" \/><\/figure>\n\n\n\n<p>\u603b\u7ed3\uff0c\u6838\u82af\u751f\u7269\u533b\u836f\uff0c\u5c06\u4e3a\u5168\u7403\u5ba2\u6237\u63d0\u4f9b\u4ece\u7814\u53d1\u6837\u54c1\u5230\u5546\u4e1a\u5316\u751f\u4ea7\uff0c\u6838\u82af\u751f\u7269\u533b\u836f\u7684\u4ea7\u80fd\u548cGMP\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u7a33\u5b9a\u6ee1\u8db3\u5168\u7403mRNA\u5ba2\u6237\u5bf9\u4e8e\u539f\u6599\u7684\u9700\u6c42\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"345\" src=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627-1024x345.png\" alt=\"\" class=\"wp-image-303\" srcset=\"http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627-1024x345.png 1024w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627-300x101.png 300w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627-768x259.png 768w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627-1536x518.png 1536w, http:\/\/nugene.com.cn\/cn\/wp-content\/uploads\/2022\/05\/\u5c4f\u5e55\u622a\u56fe-2022-05-10-115627.png 1857w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u6838\u82af\u751f\u7269\u533b\u836f\u79d1\u6280\uff08\u676d\u5dde\uff09\u6709\u9650\u516c\u53f8\u6c47\u603b \u4ee580\u4ebf\u5242\u8ba1\u7b97\uff0c\u7edf\u8ba1\u5bf9\u6bd4\u4e863\u5bb6\u4e3b\u6d41\u7684mRNA\u75ab\u82d7\u5e02\u573a\u6210\u672c\u3002 \u9879\u76ee mRN [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-299","post","type-post","status-publish","format-standard","hentry","category-mrna"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u5982\u4f55\u4fdd\u969c\u5168\u7403mRNA\u75ab\u82d7\u7814\u53d1\u548c\u751f\u4ea7\u9700\u6c42\uff1f - \u6838\u82af\u751f\u7269\u533b\u836f<\/title>\n<meta name=\"description\" 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